Xeriscape gardens are designed for water conservation, focusing on drought-tolerant plants and low-maintenance landscapes. Weeds in these settings can compete for scarce water and disrupt visual harmony. Choosing the best weed killer for xeriscape means protecting plants while minimizing soil disturbance.

The products below are selective, contact, or pre-emergent formula designed to be safe around drought-tolerant plants like succulents, native grasses, and rocks.

We evaluated efficacy, rainfast time, application ease, and plant safety. Read on to discover ten top-rated options for xeriscape maintenance.

These solutions include organic and chemical options, tailored for mulch-free, gravel, and rock garden environments. Let’s explore the best weed killers to preserve your water-wise landscape.

Top 10 Weed Killers for Xeriscape Gardens

1. Preen Garden Weed Preventer

Preen Garden Weed Preventer is a long-lasting pre-emergent ideal for gravel and cactus beds. Preen Garden Weed Preventer blocks up to 200 types of weeds before they germinate. It’s gentle on established succulents and ornamental grasses.

Apply to bare soil in spring or fall and water lightly to activate. Lasts up to three months—ideal for low-maintenance landscapes. Prevents weeds without disturbing drought-tolerant plant roots.

Do not apply over live plants. Reapply seasonally for continuous protection. Keep away from edible crop zones.

2. Ortho GroundClear Driveway, Patio & Sidewalk Weed Killer

Ortho GroundClear non-selective glyphosate formula kills weeds in rock and gravel beds without plant-safe pre-emergence. Ortho GroundClear Driveway, Patio & Sidewalk Weed Killer works fast on tough xeriscape weeds between pavers. Ideal for spot-treating hardscape areas.

Visible results in 6–12 hours; rainproof once absorbed. Spray directed foliage only to prevent damage to xeric plants. Use during calm, dry conditions.

Non-selective—avoid desirable plants. Wear PPE and avoid spray drift. Reseed or replant after waiting per label.

3. Green Gobbler Vinegar Weed & Grass Killer

Green Gobbler provides an organic, contact-based solution safe for xeriscape when applied precisely. Green Gobbler Vinegar Weed & Grass Killer burns foliage within 24 hours and dries into harmless residue. It’s ideal for eradicating tiny weeds among rocks.

No dilution required and fastest when applied on sunny, dry days. Safe for use around hardened shrubs and cacti once dried. Non-systemic—may require repeat applications.

Avoid overspray on plant bases. Use handheld sprayer for precision. Reapply after heavy water runoff events.

4. Bonide BurnOut Fast Acting Weed & Grass Killer

Bonide BurnOut contains clove oil and citric acid—perfect for organic, plant-safe weed control. Bonide BurnOut Fast Acting Weed & Grass Killer is suitable for xeriscape beds near native grasses. It’s OMRI-listed and biodegradable.

Foliage browns within 24 hours; rainproof soon after drying. Spot-spray unwanted growth without affecting surrounding plants. Requires follow-up on root systems.

Protect plant bases with shields. Reapply for persistent weeds. Store away from direct sunlight.

5. Spectracide Weed Stop for Lawns & Gardens

Spectracide Weed Stop contains 2,4-D, dicamba, and MCPP for selective control of broadleaf weeds near xeric perennials. Spectracide Weed Stop for Lawns & Gardens works in gravel and mulched xeriscapes. Safe if careful to avoid succulent stems.

Visible yellowing in 5–7 days; rainproof in six hours. Spot or broadcast in low-growth weed patches. Best used during active growth seasons.

Use on calm days and avoid drift. Wear gloves and protective eyewear. Store in a cool, dry location.

6. Roundup Ready-To-Use Weed & Grass Killer III

Roundup Ready-To-Use delivers reliable non-selective control of weeds in hardscape joints and pathways. Roundup Ready-To-Use Weed & Grass Killer III dries fast and prevents weed re-emergence. Ideal for maintaining clean stone and rock surfaces in xeriscapes.

Visible effects in 3 hours; rainproof in 10 minutes. Use wand to target tight areas. Safe when avoiding runoff into plant zones.

Not plant-safe—cover succulents before spraying. Rinse applicator after use. Reapply to re-sprouting weeds.

7. Hi-Yield Brushkiller Foam

Hi-Yield Brushkiller Foam is a non-selective foam designed for precise weed kill in xeric landscapes. Hi-Yield Brushkiller Foam minimizes overspray—great for rock gardens. It clings to vertical surfaces like retaining wall cracks.

Die-off appears in 2–3 days; rainproof after drying. Ideal for spot application along edging and pots. Includes applicator for accuracy.

Not selective—avoid desirable plant roots. Wear safety gear during application. Clean tools promptly.

8. Monterey Garden Weed & Grass Killer

Monterey Garden Weed & Grass Killer uses glyphosate and pelargonic acid for quick weed elimination in xeriscapes. Monterey Garden Weed & Grass Killer is safe for post-treatment planting near drought-resistant shrubs. Fast degradation reduces chemical persistence.

Visible browning in 3–5 days; rain resistant after four hours. Use in calm weather. Ideal for pathway and rock bed maintenance.

Non-selective—shield plants. Rinse sprayer after use. Wait recommended time before planting.

9. Preen Garden Weed Preventer + Fertilizer

Preen Garden Weed Preventer + Fertilizer adds nutrients while preventing weed germination in xeric planting zones. Preen Garden Weed Preventer + Fertilizer supports plant health and suppresses weeds simultaneously. Excellent for spring and fall landscape prep.

Apply lightly over bare soil and rock; water in gently. Lasts the entire growing season. Safe for established drought-tolerant perennials.

Don’t use near non-compatible edibles. Store dry and cool. Maintain even coverage for best results.

10. Ortho GroundClear Weed & Grass Killer

Ortho GroundClear delivers glyphosate for total vegetation control in xeriscape renovation areas. Ortho GroundClear Weed & Grass Killer clears heavy weed growth before planting drought-resistant landscapes. Works effectively in rock channels and mulch-free zones.

Results appear in 6–12 hours; rainproof after absorption. Spot-treat perimeter and pathways. Avoid runoff into plant root zones.

Non-selective—use sparingly and wear full PPE. Let area dry before planting new plants. Dispose of product per label guidelines.

Buyer’s Tips for Choosing The Best Weed Killer for Xeriscape

1. Shield plants and roots: Use cardboard or fabric during spray to protect desirable vegetation.
2. Choose selective pre-emergents: Prevent weeds without risking drought-tolerant plants.
3. Opt for spot spray: Minimize chemical use in gravel and rock gardens.
4. Water lightly after pre-emergents: Activate herbicides without disturbing plants.
5. Avoid runoff: Do not spray before heavy rainfall.
6. Wear PPE: Gloves and eyewear are essential during chemical use.
7. Plan seasonal timing: Apply in spring and fall for best results in xeriscapes.

Best Weed Killer for Xeriscape (FAQs)

1. Can I use weed killers near succulents? Yes—if you shield the plants and avoid extended root exposure.
2. Do pre-emergents work in gravel beds? Yes—they prevent seed germination without disturbing rock layers.
3. Are organic options effective? Good for foliage; follow with repeat applications for full control.
4. When should I apply? Early spring and fall before weeds sprout offer best prevention.
5. Will chemicals damage desert plants? Not if applied carefully and with protection in place.
6. Can I mix herbicides with mulch dust? No—always mix with water following label directions.
7. Is rainfast time important? Yes—it ensures the product isn’t washed away before it works.

Conclusion

Maintaining a weed‑free xeriscape requires careful choice of herbicides and precision application to protect drought‑tolerant plants.

These ten Best Weed Killer for Xeriscape offer a range of pre‑emergent, contact, and non‑selective solutions calibrated for water‑wise landscapes.

Follow shielding, timing, and safety protocols to preserve your garden’s health. Combine chemical strategies with mulching and manual removal for long‑term results.

Choose the one that fits your xeriscape maintenance plan and enjoy a clean, sustainable landscape.