Blackberry bushes are persistent and invasive, often spreading rapidly across yards, fences, and pastures. Choosing the best weed killer for blackberry bushes ensures effective control without harming nearby vegetation. This guide evaluates top-rated herbicides specifically formulated to kill tough brambles and prevent regrowth.

We focus on ingredients like glyphosate, triclopyr, and brush-specific blends for targeted application. Whether you’re treating small patches or acres of overgrowth, selecting the right product is crucial. Each recommendation offers proven performance, ease of use, and long-term suppression of blackberry shoots.

Proper application techniques are also covered for maximum penetration into woody stems. From ready-to-spray bottles to concentrated brush killers, this list meets every need and budget. Say goodbye to stubborn brambles with these powerful solutions.

Top 10 Best Weed Killers for Blackberry Bushes

1. Ortho MAX Poison Ivy & Tough Brush Killer – Best Systemic Herbicide for Deep-Rooted Blackberry Bushes

Ortho MAX Poison Ivy & Tough Brush Killer is one of the most effective solutions for eliminating deep-rooted blackberry bushes and other woody plants. Formulated with triclopyr, this powerful systemic herbicide penetrates the plant’s vascular system to kill it completely—from leaves to roots. It’s specifically designed for tough brush and brambles, making it ideal for controlling stubborn blackberry infestations.

 

This ready-to-use herbicide provides long-lasting results by killing to the root and preventing regrowth for weeks. Simply spray the solution directly on the leaves and stems for maximum absorption. Visible results appear within days, and a full kill is usually achieved within a few weeks, ensuring efficient and permanent blackberry control.

Ortho MAX Poison Ivy & Tough Brush Killer is perfect for homeowners facing scattered or moderate infestations. The trigger sprayer makes application quick and mess-free, eliminating the need for mixing. Besides blackberries, it also controls poison ivy, poison oak, and other invasive plants, offering versatile protection for your yard or garden.

Pros:
• Kills to the root
• Easy to apply
• Fast visible results
• Prevents regrowth
• Works on multiple weeds
• Ready-to-use formula
• Long-lasting control

Cons:
• Not safe near lawns
• May need reapplication
• Has chemical odor

2. Crossbow Herbicide – Best Broad-Spectrum Herbicide for Controlling Blackberry Bushes

Crossbow Herbicide combines 2,4-D and triclopyr to provide effective broad-spectrum brush control, including deep-rooted blackberry bushes. It is especially popular in pastures and non-crop areas where blackberries tend to thrive. Its low volatility makes it safer to use near trees and desirable grasses, reducing the risk of damage to surrounding plants.

 

This herbicide kills woody plants to the root while allowing grasses to survive, making it ideal for large-area and agricultural applications. It mixes easily in sprayers and delivers extended coverage per gallon. Visible results typically appear within 7–14 days, providing reliable and lasting control of stubborn blackberry infestations.

Crossbow Herbicide is perfect for rural, agricultural, and large-area blackberry control. It requires proper dilution before use and should be applied during calm, dry weather to maximize effectiveness. Avoid applying during rain or windy conditions to prevent drift and ensure optimal results.

Pros:
• Kills to the root
• Broad-spectrum control
• Safe near grasses
• Extended coverage per gallon
• Effective in pastures
• Visible results in 7–14 days
• Ideal for large areas

Cons:
• Requires dilution
• Avoid windy days
• Not for crop use

3. Roundup Concentrate Poison Ivy Plus Tough Brush Killer – Best Glyphosate-Based Herbicide for Blackberry Bushes

Roundup Concentrate Poison Ivy Plus Tough Brush Killer is a concentrated, glyphosate-based formula enhanced with additional brush control ingredients to target deep-rooted blackberry bushes effectively. It becomes rainproof within 30 minutes, allowing quick action even in unpredictable weather. Available in various sizes, it suits both small yards and large acreage applications.

This herbicide penetrates tough stems and woody growth, killing blackberry roots and preventing regrowth. Ideal for mixing in tank sprayers, it works well along fence lines, yards, or larger properties. Careful handling is required to avoid damage to nearby desirable plants, as it is non-selective.

Roundup Concentrate Poison Ivy Plus Tough Brush Killer is perfect for persistent, mature blackberry clumps. It delivers long-lasting suppression, making it a reliable solution for homeowners and landowners managing stubborn infestations. Apply with caution to maximize effectiveness and protect surrounding vegetation.

Pros:
• Kills to the root
• Rainproof in 30 minutes
• Effective on woody stems
• Works on mature clumps
• Suitable for large areas
• Long-lasting suppression
• Flexible coverage sizes

Cons:
• Non-selective
• Requires careful handling
• Risk to nearby plants

4. Bayer BioAdvanced Brush Killer Plus

This dual-action formula contains triclopyr and penetrates thick stems quickly. Targets over 70 types of invasive brush, including blackberries. Kills down to the roots with extended residual activity.

Available in concentrate and ready-to-use formats. Compatible with backpack or handheld sprayers. Safe around lawns when used as directed.

Effective for heavy infestation zones. Works even in shaded, moist areas. Professional-grade results at a consumer price.

5. Southern Ag Brush Killer – Best Budget-Friendly Herbicide for Blackberry Bushes

Southern Ag Brush Killer is a concentrated, budget-friendly formula containing triclopyr for effective control of blackberry thickets and woody brush. Its flexibility allows use with surfactants to enhance penetration and coverage, ensuring thorough treatment of dense growth.

This herbicide is designed for pastures, non-crop areas, and around fences, and it works well when mixed with diesel for cut-stump treatments. Visible results typically appear within a week, providing fast and reliable control for rural or DIY land management projects.

Southern Ag Brush Killer is perfect for large-scale or cost-conscious applications. Its affordable per-acre cost and concentrated formula make it ideal for landowners managing blackberry infestations on a budget. Proper dilution and mixing are required to maximize safety and effectiveness.

Pros:
• Affordable per-acre
• Kills to the root
• Works on dense thickets
• Flexible application methods
• Visible results in 1 week
• Suitable for pastures
• Compatible with cut-stump method

Cons:
• Requires dilution
• Needs careful mixing
• Not for small areas

6. Remedy Ultra Herbicide – Best Professional-Grade Herbicide for Blackberry Bushes

Remedy Ultra Herbicide is a professional-grade brush killer that uses triclopyr to control blackberry bushes and other tough woody shrubs. Its low-odor formula makes it suitable for both basal bark and foliar spray applications, providing effective and long-lasting control of stubborn infestations.

This herbicide can be mixed with oil or water depending on the chosen application method, offering flexibility for forestry, pasture, and large property management. It provides excellent residual control, ensuring that regrowth is minimized and treated areas remain clear for extended periods.

Remedy Ultra Herbicide is ideal for severe infestations and expansive properties. Proper personal protective equipment (PPE) is required during handling, and repeated applications may be necessary in dense or heavily overgrown areas. It delivers professional, reliable results for managing even the most persistent blackberry bushes.

Pros:
• Kills to the root
• Professional-grade formula
• Effective on woody shrubs
• Flexible application methods
• Long-lasting control
• Low-odor formula
• Ideal for large properties

Cons:
• Requires PPE
• May need reapplication
• Not for small areas

7. Compare-N-Save Brush Killer – Best Economical Herbicide for Blackberry Bushes

Compare-N-Save Brush Killer is an affordable concentrate containing 8% triclopyr for targeted control of blackberry bushes and other woody brush. It mixes easily for tank sprayers and delivers visible results within 1–2 weeks, making it a reliable option for budget-conscious users.

This herbicide works effectively along fence lines, roadside ditches, and perimeter growth, controlling over 50 types of brush. Its concentrate form allows easy storage and mixing on demand, providing flexibility for small or large-scale applications. Ideal for property managers, ranchers, and landowners, it combines convenience with effective weed suppression.

Compare-N-Save Brush Killer delivers professional results without breaking the budget. Always follow safety guidelines during application to protect surrounding plants and avoid drift. Perfect for users seeking economical yet reliable blackberry control.

Pros:
• Affordable
• Kills to the root
• Works on 50+ brush types
• Visible results in 1–2 weeks
• Easy to store
• Concentrate form
• Ideal for fences and perimeters

Cons:
• Requires mixing
• Follow safety guidelines
• Not for sensitive plants

8. Gordon’s Brush Killer for Large Properties – Best Concentrate Herbicide for Blackberry Bushes

Gordon’s Brush Killer for Large Properties is specially formulated to control blackberry bushes and other woody brush over large areas. The 1-gallon concentrate can treat up to an acre and is compatible with ATV or tow-behind sprayers, making it ideal for farms, ranches, and unmanaged lots.

This herbicide contains triclopyr, providing a systemic kill that penetrates woody plants down to the roots. Safe for use around livestock after the foliage has dried, it delivers reliable control without harming animals or surrounding soil. Results typically appear within 1–3 weeks, ensuring long-lasting suppression of stubborn blackberry growth.

Gordon’s Brush Killer is recommended for large-scale use due to its affordability and coverage. Care should be taken to avoid drift to nearby crops or desirable plants during application. Perfect for landowners managing extensive blackberry infestations, it combines efficiency with practicality for large properties.

Pros:
• Kills to the root
• Treats up to 1 acre
• Systemic action
• Safe for livestock
• Ideal for large properties
• Compatible with sprayers
• Affordable for scale

Cons:
• Results take 1–3 weeks
• Avoid drift
• Not for small areas

9. BioSafe Weed & Grass Killer – Best Organic Herbicide for Blackberry Foliage

BioSafe Weed & Grass Killer is a non-selective organic herbicide that kills blackberry foliage on contact. It uses fatty acids to burn plant tissue quickly, providing fast visual results for eco-conscious users. Ideal for those who want immediate effectiveness without synthetic chemicals, especially near gardens or sensitive areas.

 

This herbicide is safe for pets and children once the foliage has dried. Since it does not kill roots, repeated applications may be necessary to control regrowing blackberry shoots. Best results are achieved on young or regrowing shoots, making it ideal for spot treatment rather than mature bushes.

BioSafe Weed & Grass Killer is OMRI-listed for organic gardening and works well in small areas or near desirable plants. It provides a safe and environmentally friendly option for controlling blackberry leaves. However, it is not effective for root kill, so long-term management requires persistence.

Pros:
• Organic formula
• Kills foliage fast
• Safe for pets and children
• Immediate visual results
• OMRI-listed
• Ideal for spot-treatment
• Eco-friendly

Cons:
• Doesn’t kill roots
• Repeated application needed
• Not for mature bushes

10. Spectracide Weed & Grass Killer – Best Fast-Acting Herbicide for Blackberry Bushes

Spectracide Weed & Grass Killer is a fast-acting formula that effectively kills blackberry bushes to the root. Rainproof within 15 minutes, it delivers visible results in just a few hours. Available in convenient trigger bottles and concentrate options, it’s easy to apply for small-scale areas around homes and yards.

 

This herbicide contains diquat and glyphosate, providing quick action against blackberry roots and other tough weeds. It works well on driveways, patios, and areas around foundations, making it ideal for homeowners managing scattered infestations. Care must be taken to avoid overspray on desirable plants, as it is non-selective.

Spectracide Weed & Grass Killer is perfect for smaller blackberry infestations where fast results are needed. Reapplication may be necessary for larger or denser growth. Not suitable for heavy brush, but reliable for quick control in confined spaces.

Pros:
• Fast-acting
• Kills to the root
• Rainproof in 15 minutes
• Easy application
• Works on patios and driveways
• Convenient bottle options
• Visible results in hours

Cons:
• Not for heavy brush
• May require reapplication
• Non-selective

Buyers Guide Tips To Consider when Choosing The Best Weed Killer For Blackberry Bushes

1. Identify the Active Ingredient
Always check if the product contains proven brush-killing chemicals like triclopyr or glyphosate. These penetrate woody stems and ensure root kill. Products without these may only suppress foliage temporarily.

2. Choose Based on Application Area
Consider the size and accessibility of the area being treated. Large acreages may benefit from tow-behind sprayers with concentrated formulas. Smaller yards may need ready-to-use or handheld options.

3. Consider Selectivity
Some weed killers are non-selective and will kill all vegetation they touch. If you want to preserve grass or nearby plants, look for selective brush killers that target only woody weeds like blackberry bushes.

4. Check Rainfast Time
Weather plays a big role in herbicide effectiveness. Products that are rainproof within 15–30 minutes ensure performance even if the weather changes. Always apply on a dry day with no rain forecast.

5. Review Safety and Environmental Impact
Look for eco-friendly or OMRI-listed products if safety around pets, kids, or water sources is a concern. Organic weed killers offer safer options but may require more frequent reapplication for full control.

6. Determine Ease of Use
Some formulas come ready-to-use with built-in sprayers, while others need dilution and spraying tools. Pick one that matches your experience level and equipment availability. Simpler solutions save time and effort.

7. Evaluate Cost vs. Coverage
Compare the cost per gallon and how much area it treats. Some concentrates seem expensive but treat several acres when diluted. Balancing price and efficiency helps manage your budget effectively.

Best Weed Killer for Blackberry Bushes  FAQs

1. What ingredients work best for blackberries?
Triclopyr and glyphosate are most effective. These penetrate woody stems and kill roots. Avoid weak general weed killers.

2. How do I apply herbicide on thick blackberry growth?
Use a sprayer for foliar coverage. Apply to full leaf coverage for best results. Reapply if growth continues.

3. Should I cut bushes before spraying?
Yes, cutting encourages regrowth with tender leaves. Then apply weed killer when new shoots emerge. This ensures better absorption.

4. Are multiple applications needed?
Yes, especially for older or larger infestations. Repeat every few weeks as needed. Consistency is key.

5. Can I kill blackberries organically?
Yes, but organic options like fatty acid sprays require persistence. They don’t kill roots. Repeated use is necessary.

6. Is spraying harmful to nearby grass?
Some herbicides are selective and won’t hurt grass. Read the label. Non-selective formulas will kill all plants.

7. When is the best time to spray?
Late summer or early fall when blackberries are actively growing. Avoid rain and wind. Apply during warm, dry days.

Conclusion

Blackberry bushes can take over quickly if left unchecked. The best weed killers for blackberry bushes ensure fast kill, deep root penetration, and long-lasting results. Products like Crossbow and Ortho MAX deliver excellent control in large and small spaces alike.

Choosing the right formula—whether chemical or organic—depends on your land, safety preferences, and the severity of the infestation. Always follow label instructions and wear protective gear for safe use. Apply consistently and you’ll eliminate blackberries over time.

Don’t let blackberries dominate your landscape. Pick the right weed killer and restore control of your property. Persistent treatment with proven products makes all the difference.